The androgen receptor is a protein found in the nucleus of certain cells, to which male hormones (testosterone and dihydrotestosterone) bind. This receptor is normally found in the male urogenital system and in areas where hair typically grows in men.
The binding of male hormones to the androgen receptor occurs due to the structural complementarity between these molecules, much like a lock and key system. This binding leads to a series of chemical reactions that culminate in the expression of certain genes.
In the case of prostate cancer, this expression results in cell proliferation. Therefore, prostate cancer is said to be dependent on male hormones for its development and progression, which is why hormone therapy is used in its treatment. In some cases, prostate cancer can become independent of the stimulation of these hormones, among other causes due to alterations in the androgen receptor.
For more information on prostate cancer, refer to the “Prostate Cancer” section.
For more information on hormone therapy, refer to the “Frequently Asked Questions – Hormone Therapy” section.
